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MAVS/VISA Rabbit anti-Human, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Supplier: Bethyl Laboratories, Inc A300783A
Description
The recommended shelf life for this product is 1 year from date of receipt.
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKK-a, IKK-b and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.Specifications
| MAVS/VISA | |
| Polyclonal | |
| Unconjugated | |
| MAVS | |
| CARD adapter inducing interferon beta; CARD adapter inducing interferon-beta; CARD adaptor inducing IFN-beta; IFN-B promoter stimulator 1; interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; mitochondrial anti-viral signaling protein; mitochondrial antiviral-signaling protein; putative NF-kappa-B-activating protein 031N; virus-induced signaling adapter variant 1b; virus-induced signaling adaptor variant 1a; virus-induced-signaling adapter | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 57506 | |
| 4° C | |
| Liquid |
| Immunoprecipitation | |
| 1 mg/ml | |
| phosphate, tris citrate with 0.09% sodium azide; pH 7-8 | |
| Q7Z434 | |
| MAVS | |
| Between 250 and 300 | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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