Potassium channel modulator. Acts as a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells. Displays negative modulatory activity at Kv7.1 channels (Ki = 3.7µM) and GABAA receptors. Displays anxiolytic activity in vivo.
Chemical Name: (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one
CAS Number: 187523-35-9
Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
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