Invitrogen™ MB67 Polyclonal Antibody

Catalog No.	Quantity
PIPA5120678	100 μL

Catalog No. PIPA5120678 Supplier Invitrogen™ Supplier No. PA5120678

Description

Rabbit Polyclonal Antibody

Positive test controls include: HT-29, Mouse liver, Rat liver. The target is usually found in the following locations: Cytoplasm, Nucleus, cytoskeleton. Immunogen sequence: PVQLSKEQEE LIRTLLGAHT RHMGTMFEQF VQFRPPAHLF IHHQPLPTLA PVLPLVTHFA DINTFMVLQV IKFTKDLPVF RSLPIEDQIS LLKGAAVEIC HIVLNTTFCL QTQNFLCGPL RYTIEDGARV SPTVGFQVEF LELLFHFHGT LRKLQLQEPE YVLLAAMALF SPDRPGVTQR DEIDQLQEEM ALTLQSYIKG QQRRPRDRFL YAKLLGLLAE LRSINEAYGY QIQHIQGLSA MMPLLQEICS.

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists.

Specifications

• Antigen: MB67
• Applications: ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1.9 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene: NR1I3
• Gene Accession No.: O35627, Q14994, Q9QUS1
• Gene Alias: AA209988; AI551208; Car; CAR1; CAR-beta; Care2; constitutive activator of retinoid response; constitutive active receptor; constitutive active response; constitutive androstane nuclear receptor variant 2; constitutive androstane nuclear receptor variant 3; constitutive androstane nuclear receptor variant 4; constitutive androstane nuclear receptor variant 5; constitutive androstane receptor; constitutive androstane receptor NR1I3; constitutive androstane receptor protein variant 1; constitutive androstane receptor protein variant 2; constitutive androstane receptor protein variant 3; constitutive androstane receptor protein variant 4; constitutive androstane receptor protein variant 5; constitutively transactivates RAREs; ESTM32; MB67; MGC150433; MGC97144; MGC97209; NR1I3; nuclear receptor; nuclear receptor constitutive active receptor; nuclear receptor subfamily 1 group I member 3; nuclear receptor subfamily 1, group I, member 3; orphan nuclear hormone receptor; orphan nuclear receptor MB67; strain Fischer nuclear receptor (CAR); Unknown (protein for MGC:137128)
• Gene Symbols: NR1I3
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 103-352 of human NR1I3 (NP_001070948.1).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12355, 65035, 9970
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov