Invitrogen™ MB67 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529866

Catalog No. PIPA529866

Description

Recommended positive controls: mouse liver. Predicted reactivity: Rat (80%), Rhesus Monkey (96%), Chimpanzee (100%), Bovine (81%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists.

Specifications

• Antigen: MB67
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NR1I3
• Gene Alias: AA209988; AI551208; Car; CAR1; CAR-beta; Care2; constitutive activator of retinoid response; constitutive active receptor; constitutive active response; constitutive androstane nuclear receptor variant 2; constitutive androstane nuclear receptor variant 3; constitutive androstane nuclear receptor variant 4; constitutive androstane nuclear receptor variant 5; constitutive androstane receptor; constitutive androstane receptor NR1I3; constitutive androstane receptor protein variant 1; constitutive androstane receptor protein variant 2; constitutive androstane receptor protein variant 3; constitutive androstane receptor protein variant 4; constitutive androstane receptor protein variant 5; constitutively transactivates RAREs; ESTM32; MB67; MGC150433; MGC97144; MGC97209; NR1I3; nuclear receptor; nuclear receptor constitutive active receptor; nuclear receptor subfamily 1 group I member 3; nuclear receptor subfamily 1, group I, member 3; orphan nuclear hormone receptor; orphan nuclear receptor MB67; strain Fischer nuclear receptor (CAR); Unknown (protein for MGC:137128)
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12355, 9970
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O35627, Q14994
• Gene Symbols: NR1I3
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 1 and 127 of Human NR1I3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov