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Invitrogen™ MBD1 Recombinant Rabbit Monoclonal Antibody (10B10)
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Catalog No. FEMA549992
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100 μL
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FEMA549992 100 μL
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Catalog No. FEMA549992 Supplier Invitrogen™ Supplier No. MA549992
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Description

Rabbit Recombinant Monoclonal Antibody

MBD1 Recombinant Monoclonal Antibody for ICC/IF, ELISA

Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MBD1
Applications ELISA, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 10B10
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene MBD1
Gene Accession No. Q9UIS9
Gene Alias CXXC3; CXXC-type zinc finger protein 3; Mbd1; methyl-CpG binding domain protein 1; methyl-CpG binding domain protein 1 isoform PCM1; methyl-CpG-binding domain protein 1; Methyl-CpG-binding protein MBD1; PCM1; Protein containing methyl-CpG-binding domain 1; RFT; the regulator of fibroblast growth factor 2 (FGF-2) transcription
Gene Symbols MBD1
Host Species Rabbit
Immunogen A synthesized peptide derived from human MBD1.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4152
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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