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Invitrogen™ MBNL3 Isoform G Polyclonal Antibody
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Catalog No. PIPA521836
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100 μL
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PIPA521836 100 μL
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Catalog No. PIPA521836 Supplier Invitrogen™ Supplier No. PA521836
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, HeLaS3, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (86%), Rat (87%), Bovine (87%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

MBNL3 (Muscleblind-like protein 3) is an RNA-binding protein involved in the regulation of alternative splicing. The gene encodes several isoforms, including MBNL3 isoform G, which has distinct roles in RNA metabolism and splicing. MBNL3 isoform G contains functional domains necessary for RNA binding and splicing regulation, which are separate from its RNA-binding zinc finger domains. The expression of MBNL3 is particularly noted in proliferating cells where it can inhibit the transcription of muscle-specific genes, thereby impacting myogenesis. This isoform has also been implicated in the regulation of muscle regeneration; knockout models of MBNL3 show impaired muscle regeneration and delayed response to injury. The nuanced regulation by MBNL3 isoform G suggests its importance in muscle biology and its involvement in RNA processing complexities that underpin muscle development and repair.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MBNL3 Isoform G
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.92 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Mbnl3
Gene Accession No. Q9NUK0
Gene Alias CHCR; Cys3His CCG1-required protein; MBLX; MBLX39; MBNL3; MBXL; muscleblind like splicing regulator 3; muscleblind-like 3; muscleblind-like protein 3; muscleblind-like splicing regulator 3; muscleblind-like X-linked protein; Protein HCHCR; RP5-842K24.3
Gene Symbols Mbnl3
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human MBNL3. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55796
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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