MBP Polyclonal Antibody, Invitrogen™

Chicken Polyclonal Antibody

Supplier:  Thermo Scientific PA110008

Catalog No. 01-670-265

Description

In Western blot using rat spinal cord whole tissue homogenates, this antibody detects all isotypes of MPB, resulting in bands at ∽21.5kDa, 18.5kDa, 17kDa and 14kDa. ∣Stable at 4°C for at least one year.

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "e;Golli-MBP"e;) that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Specifications

• Antigen: MBP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MBP
• Gene Alias: 20 kDa microtubule-stabilizing protein; C76307; golli mbp; Golli-mbp; Golli-MBP; myelin basic protein; Golli-Mbp; myelin basic protein; myelin basic protein S; Hmbpr; MBP; MBP S; Mbps; MGC99675; microtubule-stabilizing protein; mLd; MOBP; Myelin A1 protein; myelin basic protein; myelin basic protein Golli-mbp; myelin basic protein S; myelin deficient; myelin membrane encephalitogenic protein; Myelin P1 protein; myelin-associated oligodendrocyte basic protein; R75289; shi; shiverer; Unknown (protein for IMAGE:7984318); unnamed protein product
• Host Species: Chicken
• Purification Method: PEG precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 17196, 24547, 414286, 4155, 618684
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
• Concentration: Conc. Not Determined
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P02686, P02687, P02688, P04370, P81558
• Gene Symbols: MBP
• Immunogen: Full length purified myelin basic protein isolated from cow nerve
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Bovine, Human, Mouse, Pig, Rat
• Product Type: Antibody
• Isotype: IgY

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov