Invitrogen™ MBTPS1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563247

Catalog No. PIPA563247

Description

Immunogen sequence: YPPGYFPRDN LRMKNDPLDW NGDHIHTNFR DMYQHLRSMG YFVEVLGAPF TCFDASQYGT LLMVDSEEEY FPEEIAKLRR DVDNGLSLVI FSDWYNTSVM RKVKFYDENT RQWWMPDTGG ANIPALNELL SV Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 97%.

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction.

Specifications

• Antigen: MBTPS1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MBTPS1
• Gene Alias: 0610038M03Rik; AV003995; endopeptidase S1P; KIAA0091; MBTPS1; membrane bound transcription factor peptidase, site 1; membrane-bound transcription factor peptidase, site 1; membrane-bound transcription factor protease, site 1; membrane-bound transcription factor site-1 protease; mKIAA0091; PCSK8; proprotein convertase subtilisin/kexin type 8; S1p; S1P endopeptidase; site-1 protease; Ski1; SKI-1; Sterol-regulated luminal protease; subtilisin kexin isozyme 1; subtilisin/kexin isozyme 1; subtilisin/kexin isozyme SKI-1; subtilisin/kexin isozyme-1; Subtilisin/kexin-isozyme 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8720
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q14703
• Gene Symbols: MBTPS1
• Immunogen: Recombinant protein corresponding to Human MBTPS1. Recombinant protein control fragment (Product #RP-104051).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG