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Tocris Bioscience™ MC 1742
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Catalog No. 572710
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57-271-0 10 mg
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Catalog No. 57-271-0 Supplier Tocris Bioscience™ Supplier No. 5727/10
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Description

Potent class I and IIb HDAC inhibitor

MC 1742 is a potent class I and IIb HDAC inhibitor (IC50 values are 7, 20, 40, 100, 110 and 610 nM for HDAC6, HDAC3, HDAC10, HDAC1, HDAC2 and HDAC8, respectively). Suppresses proliferation and induces apoptosis of sarcoma cancer stem cells (CSCs) at concentrations >500 nM. Also induces osteogenesis in sarcoma CSCs at concentrations of 25 - 500 nM .

Specifications

Chemical Name or Material 5-[(4-[1,1′-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide
CAS 1776116-74-5
Quantity 10 mg
Target Histone Deacetylase Inhibitors
Molecular Formula C21H21N3O3S
Formula Weight 395.47
Purity >98%
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