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MCAM Mouse anti-Human, Clone: OTI3D1, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF803467

Catalog No. 50-166-6513


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 is expressed at cell-cell junctions in all endothelial cells, and has also been observed in other normal and maligt cell types. In addition to its recognized role as a calcium-independent cell adhesion molecule, CD146 may also act as a signal transduction molecule in the recruitment of Fyn kinase, and in the subsequent tyrosine-phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. CD146 expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Further, CD146 could be an adhesion molecule active in neural crest cells during embryonic development. CD146 acts also as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
Specifications

Specifications

MCAM
Monoclonal
Unconjugated
MCAM
Lyophilized
MCAM
Full length human recombit protein of human MCAM produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Western Blot
OTI3D1
PBS with 8% trehalose and no preservative; pH 7.3
P43121
CD146, MUC18
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
4162
SDS
Documents
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