Invitrogen™ MCHR2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA575329

Catalog No. PIPA575329

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic neuropeptide which is mainly expressed in the hypothalamus. MCH modulates feeding behavior, aggression, anxiety, arousal and reproductive function in mammals by controlling the release of luteinizing hormone (LH). The melanin-concentrating hormone receptor (MCHR, also designated SLC-1) is a glycosylated G-protein coupled receptor that migrates between 45-50 kDa on SDS-PAGE. MCHR mediates the effects of MCH through Gai and/or Gaq signaling and is expressed in several regions of the brain, including the cerebral cortex, amygdala, thalamus and hypothalamus. MCH and MCHR have also been implicated in stimulating leptin expression and secretion in adipocytes, which suggests that the melanin-concentrating hormone and its receptor may be potential targets for modulating obesity.

Specifications

• Antigen: MCHR2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MCHR2
• Gene Alias: G protein-coupled receptor 145; G protein-coupled receptor slt; GPR145; G-protein coupled receptor 145; GPRv17; MCH receptor 2; MCH2; Mch2 receptor; MCH2R; MCH-2R; MCHR2; MCH-R2; MCHR-2; melanin concentrating hormone receptor 2; melanin-concentrating hormone 2; melanin-concentrating hormone receptor 2; SLT; SLT receptor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84539
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q969V1
• Gene Symbols: MCHR2
• Immunogen: Synthetic peptide corresponding to amino acids 300-340 of Human MCH-2R.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG