Invitrogen™ MCHR2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532918

Catalog No. PIPA532918

Description

Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon (94%); Monkey, Marmoset (89%); Panda, Pig (83%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic neuropeptide which is mainly expressed in the hypothalamus. MCH modulates feeding behavior, aggression, anxiety, arousal and reproductive function in mammals by controlling the release of luteinizing hormone (LH). The melanin-concentrating hormone receptor (MCHR, also designated SLC-1) is a glycosylated G-protein coupled receptor that migrates between 45-50 kDa on SDS-PAGE. MCHR mediates the effects of MCH through Gai and/or Gaq signaling and is expressed in several regions of the brain, including the cerebral cortex, amygdala, thalamus and hypothalamus. MCH and MCHR have also been implicated in stimulating leptin expression and secretion in adipocytes, which suggests that the melanin-concentrating hormone and its receptor may be potential targets for modulating obesity.

Specifications

• Antigen: MCHR2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MCHR2
• Gene Alias: G protein-coupled receptor 145; G protein-coupled receptor slt; GPR145; G-protein coupled receptor 145; GPRv17; MCH receptor 2; MCH2; Mch2 receptor; MCH2R; MCH-2R; MCHR2; MCH-R2; MCHR-2; melanin concentrating hormone receptor 2; melanin-concentrating hormone 2; melanin-concentrating hormone receptor 2; SLT; SLT receptor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84539
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: Q969V1
• Gene Symbols: MCHR2
• Immunogen: Synthetic 18 amino acid peptide from C-terminal cytoplasmic domain of human MCHR2.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov