Invitrogen™ MCK10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA130315

Catalog No. PA130315

Description

Detects a band at approximately 100 kDa (predicted molecular weight of 105 kDa). Positive control of placenta lysate suggested.

DDR1 is a receptor tyrosine kinase activated by collagen and is reported to regulate adhesion, cell migration and other cellular processes. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

Specifications

• Antigen: MCK10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DDR1
• Gene Alias: 6030432F18; AI323681; Cak; CD167; CD167 antigen-like family member A; CD167a; Cell adhesion kinase; DAAP-278B20.1; DDR; DDR1; DDR1d; discoidin domain receptor family, member 1; discoidin domain receptor tyrosine kinase 1; discoidin receptor tyrosine kinase; Drd1; Eddr1; Epithelial discoidin domain receptor 1; epithelial discoidin domain-containing receptor 1; HGK2; mammary carcinoma kinase 10; MCK10; MCK-10; Mpk6; NEP; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase receptor type 4; neurotrophic tyrosine kinase, receptor, type 4; NTRK4; protein-tyrosine kinase 3; Protein-tyrosine kinase 3A; Protein-tyrosine kinase MPK-6; protein-tyrosine kinase PTK-3; protein-tyrosine kinase RTK-6; PTK3; PTK3A; PTK3A protein tyrosine kinase 3A; PTK3D; RTK6; TRK E; TRKE; Tyrosine kinase DDR; tyrosine-protein kinase CAK
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 25678, 780
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q08345, Q63474
• Gene Symbols: DDR1
• Immunogen: KLH conjugated synthetic peptide between 17-47 amino acids from the N-terminal region of human DDR1.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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