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Invitrogen™ MCM10 Polyclonal Antibody
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Catalog No. PIPA5121074
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100 μL
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PIPA5121074 100 μL
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Catalog No. PIPA5121074 Supplier Invitrogen™ Supplier No. PA5121074
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Description

Rabbit Polyclonal Antibody

Positive test controls include: Jurkat. The target is usually found in the following locations: Nucleus. Immunogen sequence: RLEGAPATMT PKLGRGVLEG DDVLFYDESP PPRPKLSALA EAKKLAAITK LRAKGQVLTK TNPNSIKKKQ KDPQDILEVK ERVEKNTMFS SQAEDELEPA RKKRREQLAY LESEEFQKIL KAKSKHTGIL KEAEAEMQER YFEPLVKKEQ MEEKMRNIRE VKCRVVTCKT CAYTHFKLLE TCVSEQHEYH WHDGVKRFFK CPCGNRSISL DRLPNKHCSN CGLYKWERDG MLKEKTGPKI GGETLLPRGE EHAKFLNSLK.

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MCM10
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.54 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene MCM10
Gene Accession No. Q0VBD2, Q7L590
Gene Alias 2410041F14Rik; AU018508; C330019M07Rik; C79164; CNA43; DNA43; homolog of yeast MCM10; hsMCM10; Mcm10; MCM10 minichromosome maintenance deficient 10; MGC126776; minichromosome maintenance 10 replication initiation factor; minichromosome maintenance complex component 10; minichromosome maintenance deficient 10; minichromosome maintenance deficient 10 (S. cerevisiae); PRO2249; Protein MCM10 homolog
Gene Symbols MCM10
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 616-875 of human MCM10 (NP_8774281).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 307126, 55388, 70024
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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