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MCM4/CDC21 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981246
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50-198-1246 100 μL
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Catalog No. 50-198-1246 Supplier Bioss Supplier No. BS11298R
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Description

Rabbit Polyclonal Antibody

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Specifications

Antigen MCM4/CDC21
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Mcm4
Gene Accession No. P33991
Gene Alias 19G; AI325074; AU045576; BOS_13786; cb1025; CDC21; CDC21 homolog; CDC54; DNA replication licensing factor MCM4; fc12c09; fj85g09; hCdc21; hm:zeh1616; homolog of S. pombe cell devision cycle 21; LOC100349822; mcdc21; Mcm4; MCM4 minichromosome maintenance deficient 4; MCM4 minichromosome maintenance deficient 4, mitotin; mcm4 protein; Mcmd4; mini chromosome maintenance deficient 4 homolog; minichromosome maintenance complex component 4; minichromosome maintenance deficient 4; minichromosome maintenance deficient 4 homolog; minichromosome maintenance deficient 4 homolog (S. cerevisiae); mKIAA4003; NKCD; NKGCD; P1-CDC21; wu:fc12c09; wu:fj85g09; zeh1616
Gene Symbols Mcm4
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human MCM4.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4173
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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