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MCM7 Monoclonal Antibody (47DC141 (DCS-141)), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA514291

Catalog No. PIMA514291


Description

Description

MA5-14291 targets CDC47 in IF, IHC (P), IP, and WB applications and shows reactivity with Canine, Human, mouse, Rat, and Xenopus laevis samples. The MA5-14291 immunogen is recombinant hCDC47 protein.

MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

MCM7
Monoclonal
0.2 mg/mL
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
P33993, Q61881, Q91876
Mcm7, mcm7.S
Recombinant hCDC47 protein
500 μL
Primary
Canine, Human, Mouse, Rat, X. laevis
Antibody
IgG1
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
47DC141 (DCS-141)
Unconjugated
Mcm7
AI747533; CDC47; CDC47 homolog; CDC47 homolog A; CDC47p; DNA replication licensing factor MCM7; DNA replication licensing factor mcm7-A; DNA replication licensing factor MCM7-like protein; homolog of S. cerevisiae Cdc47; mCDC47; MCM2; MCM7; MCM7 minichromosome maintenance deficient 7; mcm7.S; mcm7-a; mcm7-b; Mcmd7; mini chromosome maintenance deficient 7; minichromosome maintenance complex component 7; minichromosome maintenance complex component 7 S homeolog; minichromosome maintenance deficient 7; minichromosome maintenance deficient 7 (S. cerevisiae); minichromosome maintenance protein 7; minichromosome maintenance protein 7-A; P1 P85MCM; P1.1-MCM3; P1CDC47; P85MCM; p90; PNAS146; PPP1R104; protein phosphatase 1, regulatory subunit 104; Unknown (protein for MGC:128845); XELAEV_18000877mg; XMCM7; xMCM7-A
Mouse
Protein G
RUO
17220, 288532, 397852, 4176, 479737
4° C
Liquid
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