Invitrogen™ MCP-4 Monoclonal Antibody (3G4)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ M809

Catalog No. PIM809

Description

There is one major form (long chain) and two minor forms (short chain and medium chain) of MCP-4 produced by differential signal peptide cleavage. Thus, the resulting MW of secreted MCP-4 ranges between ~8-9kD. Western blot analysis of recombinant MCP-4/CCL13 protein detects an ~17kD band, likely corresponding to a dimer of MCP-4. The M809 MCP-4 antibody (clone 3G4) has successfully been paired as the coating antibody in a sandwich ELISA with detection antibody M810 (biotinylated conjugate of clone 8C12). The M809 MCP-4 antibody (biotinylated conjugate of clone 3G4) has also been used successfully in a sandwich ELISA as a detection antibody when paired with M810 (clone 8C12) as the coating antibody.

Monocyte Chemotactic Protein 4 (MCP-4), also called CCL13, is induced by inflammatory proteins such as IL-1 and TNFalpha. MCP-4 is a ligand for three different G protein coupled receptors, CCR2, CCR3 and CCR5. MCP-4 activates signaling in monocytes, T lymphocytes, eosinophils and basophils and this signaling is associated with the allergic response.

Specifications

• Antigen: MCP-4
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q99616
• Gene Symbols: CCL13
• Immunogen: Recombinant CCL13 protein.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Western Blot
• Clone: 3G4
• Conjugate: Unconjugated
• Gene: CCL13
• Gene Alias: C-C motif chemokine 13; C-C motif chemokine 13, long chain; C-C motif chemokine 13, medium chain; C-C motif chemokine 13, short chain; C-C motif chemokine ligand 13; CCL 13; CCL13; chemokine (C-C motif) ligand 13; CKb10; CK-beta-10; H-MCP-4; MCP4; MCP-4; Monocyte chemoattractant protein 4; monocyte chemotactic protein 4; NCC1; NCC-1; new CC chemokine 1; SCYA13; SCYL1; small inducible cytokine subfamily A (Cys-Cys), member 13; small-inducible cytokine A13
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 6357
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

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