Invitrogen™ MCRS1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5119815

Catalog No. PIPA5119815

Description

Positive Control: SH-SY5Y cell lysates, rat large intestine tissue, human liver tissue, human pancreas tissue, mouse testis tissue. Subcellular Location: Nucleus, Nucleolus, Cytoplasm.

Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602). [UniProt].

Specifications

• Antigen: MCRS1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MCRS1
• Gene Alias: 58 kDa microspherule protein; C78274; cell cycle-regulated factor (78 kDa); cell cycle-regulated factor p78; ICP22BP; INO80 complex subunit J; INO80 complex subunit Q; INO80Q; Mcrs1; MCRS2; Microspherule protein 1; MSP58; nucleolar protein; P78
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10445, 300222, 51812
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q96EZ8, Q99L90
• Gene Symbols: MCRS1
• Immunogen: Recombinant protein within human MCRS1 aa 1-200.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG