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MCT8 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

$151.31

Specifications

Antigen MCT8
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Form Liquid
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-156-7499
Encompass_Preferred
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Bethyl Laboratories, Inc
A304351AT
20 μL
Each of 1 for $151.31
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Description

Description

The recommended shelf life for this product is 1 year from date of receipt.

Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT 1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. Defects in the gene encoding for MCT8, SLC16A2, can cause monocarboxylate transporter 8 deficiencey (MCT8 deficiency), a defect in cellular hormone transport causing a severe form of X-linked psychomotor retardation and abnormal thyroid levels.
Specifications

Specifications

MCT8
Polyclonal
Liquid
RUO
TBS with 0.1% BSA and 0.09% sodium azide
Monocarboxylate transporter 8, MCT 8, Monocarboxylate transporter 7, MCT 7, MCT7, Solute carrier family 16 member 2, X-linked PEST-containing transporter, MCT8, XPCT
Between 250 and 300
Primary
4° C
SLC16A2
Western Blot
Unconjugated
Rabbit
Human, Mouse
O70324, P36021
20502, 6567
IgG
Antigen affinity chromatography
Antibody
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