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MCT8 Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Catalog No. 501567497
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50-156-7497 100 μL
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Catalog No. 50-156-7497 Supplier Bethyl Laboratories, Inc Supplier No. A304351A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT 1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. Defects in the gene encoding for MCT8, SLC16A2, can cause monocarboxylate transporter 8 deficiencey (MCT8 deficiency), a defect in cellular hormone transport causing a severe form of X-linked psychomotor retardation and abnormal thyroid levels.

Specifications

Antigen MCT8
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene SLC16A2
Gene Accession No. O70324, P36021
Gene Alias Monocarboxylate transporter 8, MCT 8, Monocarboxylate transporter 7, MCT 7, MCT7, Solute carrier family 16 member 2, X-linked PEST-containing transporter, MCT8, XPCT
Gene Symbols SLC16A2
Host Species Rabbit
Immunogen Between 250 and 300
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20502, 6567
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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