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MCU/CCDC109A Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501735302 Shop All Proteintech Group Inc Products
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50-173-5302 150 μL
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Catalog No. 50-173-5302 Supplier Proteintech Group Inc Supplier No. 263121AP150UL
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Description

Rabbit Polyclonal Antibody

Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a ′fight-or-flight′ response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. participates in mitochondrial permeability transition during ischemia-reperfusion injury. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults. Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation.

Specifications

Antigen MCU/CCDC109A
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Polyclonal
Concentration 0.35 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene MCU
Gene Accession No. Q8NE86
Gene Alias C10orf42, Calcium uniporter protein, CCDC109A, MCU
Gene Symbols MCU
Host Species Rabbit
Immunogen MCU/CCDC109A Fusion Protein Ag24733
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 90550
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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