Invitrogen™ MD-1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520261

Catalog No. PIPA520261

Description

A suggested positive control is Daudi cell lysate. PA5-20261 can be used with blocking peptide PEP-0376.

MD-1, also known as LY86, is a glycoprotein involved in innate immunity. It is a component of the RP105/MD-1 complex, which is expressed primarily in immune cells like B-cells. MD-1 is structurally similar to MD-2, sharing only 16% sequence identity, yet both are implicated in lipopolysaccharide recognition. The protein contains the ML (MD-2-related lipid-recognition) domain, which is conserved across various species and mediates diverse biological functions by interacting with specific lipids. Structurally, MD-1 is characterized by a beta-rich fold consisting of multiple strands, which is integral to its biological activities. Though MD-1 mainly associates with RP105, its role in lipid recognition suggests functional similarities with proteins such as GM2A and NPC2, implying participation in broader immune signaling pathways.

Specifications

• Antigen: MD-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LY86
• Gene Alias: dJ80N2.1; Ly86; Ly-86; Lymphocyte antigen 86; MD1; MD-1; MD-1, RP105-associated; MMD-1; Protein MD-1; RP1-80N2.1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17084, 291359, 9450
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: O88188, O95711
• Gene Symbols: LY86
• Immunogen: A 15 amino acid peptide from near the center of human MD-1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG