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Tocris Bioscience™ MD13
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Catalog No. 75035
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Quantity:
5 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent MIF Degrader (PROTAC™)

MD13 is a potent MIF (macrophage migration inhibitory factor) Degrader (PROTAC™) (DC50 < 100 nM; Dmax = 92% after 6 h). MD13 comprises the cereblon ligand Pomalidomide (Cat. No. 6302) joined by a linker to a MIF inhibitor. MD13 reduces MIF levels, arrests cells at the G2/M phase and inhibits proliferation of A549 lung carcinoma cells. Growth of A549 cell 3D spheroids is also inhibited by MDF13.

Negative control MD15 (Cat.No. 7504) also available.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material 8-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-N-(4-(7-hydroxy-2-oxo-2 H-benzo[e][1,3 ]oxazin-3(4 H)-yl)phenyl)octanamide
Quantity 5 mg
Target Active Degraders
Molecular Formula C35H35N5O8
Purity 0.98
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