Invitrogen™ MDA5 Recombinant Rabbit Monoclonal Antibody (33H12L34)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ 700360

Catalog No. PI700360

Description

This antibody is predicted to react with Rhesus monkey, mouse, rat, porcine and bovine based on sequence homology. Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation.

Specifications

• Antigen: MDA5
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q8R5F7, Q9BYX4
• Gene Symbols: IFIH1
• Immunogen: A recombinant protein corresponding to amino acids 883-1025 of Q9BYX4.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, RNA Immunoprecipitation, Immunocytochemistry
• Clone: 33H12L34
• Conjugate: Unconjugated
• Gene: IFIH1
• Gene Alias: 9130009C22Rik; AGS7; CADM-140 autoantigen; Clinically amyopathic dermatomyositis autoantigen 140 kDa; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; helicard; Helicase with 2 CARD domains; Hlcd; IDDM19; IFIH1; interferon induced with helicase C domain 1; interferon induced with helicase C domain protein 1; interferon induced, with helicase C domain 1; interferon-induced helicase C domain-containing protein 1; Interferon-induced with helicase C domain protein 1; MDA5; MDA-5; melanoma differentiation associated protein-5; melanoma differentiation-associated gene 5; melanoma differentiation-associated protein 5; MGC133047; Murabutide down-regulated protein; RGD1560496; RH116; RIG-I-like receptor 2; RLR-2; RNA helicase-DEAD box protein 116; SGMRT1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 64135, 71586
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid
• Green Features: Responsibly packaged

Safety and Handling

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