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Invitrogen™ MDMX Polyclonal Antibody
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Catalog No. PIPA127958
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50 μg
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PIPA127958 50 μg
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Catalog No. PIPA127958 Supplier Invitrogen™ Supplier No. PA127958
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: HepG2, MCF-7. Predicted reactivity: Cow: 80%; Dog: 93%; Horse: 93%; Pig: 86%; Rabbit: 80%. Use at a concentration of 1 μg/mL in 5% skim milk/PBS buffer. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The MDM2 protein is the primary regulator of p53 protein stability. MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2. The gene that encodes MDMX (also designated MDM4) is a target for amplification in malignant gliomas. ARF interacts with MDMX to sequester MDMX within the nucleolus. This sequestration of MDMX by ARF results in an increase in p53 transactivation. In addition, expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. Like MDM2, MDMX also binds p73 and stabilizes the level of p73. Therefore, in striking contrast to p53, the half-life of p73 is increased by binding to MDM2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MDMX
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene MDM4
Gene Accession No. O15151
Gene Alias 4933417N07Rik; AA414968; AL023055; AU018793; AU021806; C85810; DKFZp781B1423; double minute 4 homolog; double minute 4 protein; double minute 4, human homolog of; p53-binding protein; HDMX; human homolog of; Mdm2-like p53-binding protein; MDM4; Mdm4 p53 binding protein homolog; MDM4 protein variant G; MDM4 protein variant Y; MDM4, p53 regulator; MDM4-related protein 1; Mdmx; MGC132766; MRP1; p53-binding protein Mdm4; Protein Mdm4; protein Mdmx; RP11-430C7.1; transformed mouse 3T3 cell double minute 4
Gene Symbols MDM4
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a N-terminal region of Human MDM4.
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4194
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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