Invitrogen™ ME2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA538007

Catalog No. PIPA538007

Description

A recommended positive control is human spleen tissue lysate. At least two isoforms of ME2 are known to exist; this antibody will detect both isoforms. ME2 antibody is not expected to cross-react with ME1.

ME2 encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.

Specifications

• Antigen: ME2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Me2
• Gene Alias: AW120568; D030040L20Rik; malate dehydrogenase; malate dehydrogenase (oxaloacetate-decarboxylating); malic enzyme 2; malic enzyme 2, NAD(+)-dependent, mitochondrial; Me2; NAD-dependent malic enzyme, mitochondrial; NAD-ME; ODS1; pyruvic-malic carboxylase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4200
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P23368
• Gene Symbols: Me2
• Immunogen: 17 amino acid peptide near the center of human ME2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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