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Tocris Bioscience™ Meclizine dihydrochloride
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Catalog No. 424550
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Human pregnane X receptor agonist; H1 antagonist

Meclizine dihydrochloride is a human pregnane X receptor (hPXR) agonist; it is a more potent activator of hPXR than rat PXR. Meclizine increases hPXR target gene expression in human hepatocyte primary cultures. It also acts as a histamine H1 receptor antagonist. Meclizine attenuates mitochondrial respiration and increases glycolysis. The product inhibits rotenone-induced cell death in stem cell-derived dopaminergic neuronal culture and confers neuroprotection in models of polyglutamine (polyQ) toxicity.

Chemical Identifiers

CAS 1104-22-9
Molecular Formula C25H29Cl3N2

Specifications

Quantity 50 mg
Formula Weight 463.87
Purity >99%
Molecular Weight (g/mol) 463.871
Chemical Name or Material Meclizine dihydrochloride

Safety and Handling

Recommended Storage Desiccate at Room Temperature
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