MECP2 Mouse anti-Human, Clone:8H4A5B9, Abnova™

Catalog No.	Quantity
89-333-530	100 μg

Catalog No. 89-333-530 Supplier Abnova Corporation Supplier No. MAB17294

Description

Mouse monoclonal antibody raised against recombinant human MECP2.

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq]

Specifications

• Antigen: MECP2
• Applications: ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 8H4A5B9
• Conjugate: Unconjugated
• Description: methyl CpG binding protein 2 (Rett syndrome)
• Dilution: ELISA (1:10000)
  Flow Cytometry (1:200-400)
  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1000)
  Immunofluorescence (1:200-1000)
  Western Blot (1:500-1:2000)
  The optimal working dilution should be determined by th
• Formulation: In PBS (0.05% sodium azide)
• Gene: MECP2
• Gene Alias: AUTSX3, DKFZp686A24160, MRX16, MRX79, MRXS13, MRXSL, PPMX, RTS, RTT
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 7-148 of of human MECP2 from E. coli.
• Quantity: 100 μg
• Gene ID (Entrez): 4204
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1