Invitrogen™ MECR Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555967

Catalog No. PIPA555967

Description

Immunogen sequence: SSTELLRQLA RGGTMVTYGG MAKQPVVASV SLLIFKDLKL RGFWLSQWKK DHSPDQFKEL ILTLCDLIRR GQLTAPACSQ VPLQDYQSAL EASMKPFISS KQILTM Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 87%.

The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.

Specifications

• Antigen: MECR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mecr
• Gene Alias: 2-enoyl thioester reductase; AI195831; CGI-63; Enoyl-[acyl-carrier-protein] reductase, mitochondrial; FASN2B; homolog of yeast 2-enoyl thioester reductase; HsNrbf-1; Mecr; mitochondrial 2-enoyl thioester reductase; mitochondrial trans-2-enoyl-CoA reductase; NBRF1; Nrbf1; NRBF-1; nuclear receptor binding factor 1; nuclear receptor-binding factor 1; trans-2-enoyl-CoA reductase, mitochondrial
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26922, 51102
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BV79, Q9DCS3
• Gene Symbols: Mecr
• Immunogen: Recombinant protein corresponding to Human MECR. Recombinant protein control fragment (Product #RP-93136).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG