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Invitrogen™ MECR Polyclonal Antibody
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Catalog No. PIPA555967
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PIPA555967 100 μL
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Catalog No. PIPA555967 Supplier Invitrogen™ Supplier No. PA555967
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SSTELLRQLA RGGTMVTYGG MAKQPVVASV SLLIFKDLKL RGFWLSQWKK DHSPDQFKEL ILTLCDLIRR GQLTAPACSQ VPLQDYQSAL EASMKPFISS KQILTM Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 87%.

The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MECR
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Mecr
Gene Accession No. Q9BV79, Q9DCS3
Gene Alias 2-enoyl thioester reductase; AI195831; CGI-63; Enoyl-[acyl-carrier-protein] reductase, mitochondrial; FASN2B; homolog of yeast 2-enoyl thioester reductase; HsNrbf-1; Mecr; mitochondrial 2-enoyl thioester reductase; mitochondrial trans-2-enoyl-CoA reductase; NBRF1; Nrbf1; NRBF-1; nuclear receptor binding factor 1; nuclear receptor-binding factor 1; trans-2-enoyl-CoA reductase, mitochondrial
Gene Symbols Mecr
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human MECR. Recombinant protein control fragment (Product #RP-93136).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26922, 51102
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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