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Invitrogen™ MED11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA568219

Catalog No. PIPA568219


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Description

Description

Predicted to react with Human and Rat samples.

In mammalian cells, transcription is regulated in part by high molecular weight co-activating complexes that mediate signals between transcriptional activators and RNA polymerase II (Pol II). The mediator complex is one such multiprotein structure that functions as a bridge between regulatory proteins and Pol II, thereby regulating Pol II-dependent transcription. Med11 (mediator complex subunit 11) is a 117 amino acid nuclear protein and component of the mediator complex. The gene encoding Med11 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, and is associated with predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

MED11
Polyclonal
Unconjugated
MED11
1110030J09Rik; AI465144; AW545069; HSPC296; MED11; Mediator complex subunit 11; mediator of RNA polymerase II transcription subunit 11; mediator of RNA polymerase II transcription, subunit 11 homolog; RGD1563202
Rabbit
affinity chromatography
RUO
287456, 400569, 66172
-20°C
Liquid
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q9D8C6, Q9P086
MED11
Synthesized peptide derived from human MED11.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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