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Invitrogen™ MED11 Polyclonal Antibody
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Catalog No. PIPA5103914
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100 μL
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PIPA5103914 100 μL
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Catalog No. PIPA5103914 Supplier Invitrogen™ Supplier No. PA5103914
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total MED11.

In mammalian cells, transcription is regulated in part by high molecular weight co-activating complexes that mediate signals between transcriptional activators and RNA polymerase II (Pol II). The mediator complex is one such multiprotein structure that functions as a bridge between regulatory proteins and Pol II, thereby regulating Pol II-dependent transcription. Med11 (mediator complex subunit 11) is a 117 amino acid nuclear protein and component of the mediator complex. The gene encoding Med11 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, and is associated with predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MED11
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene MED11
Gene Accession No. Q9D8C6, Q9P086
Gene Alias 1110030J09Rik; AI465144; AW545069; HSPC296; MED11; Mediator complex subunit 11; mediator of RNA polymerase II transcription subunit 11; mediator of RNA polymerase II transcription, subunit 11 homolog; RGD1563202
Gene Symbols MED11
Host Species Rabbit
Immunogen A synthesized peptide derived from human MED11(Accession Q9P086), corresponding to amino acid residues A13-L63.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 287456, 400569, 66172
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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