MED12 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-157-1630	Bethyl Laboratories, Inc IHC00180T	10 μL
50-157-1629	Bethyl Laboratories, Inc IHC00180	100 μL

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, Dog, Pig, Panda, Orangutan, Monkey, Chimpanzee, Naked mole rat and Small-eared galag

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009].

Specifications

• Antigen: MED12
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: Kiaa0192, Mopa, Tnrc11, Trap230
• Immunogen: Between 2150 and C-term
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: MED12

• Applications: Immunohistochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: A2AGH6, Q93074
• Gene ID (Entrez): 59024, 9968
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody