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MED28 Mouse anti-Human, Clone: OTI10C8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527256

Catalog No. PIMA527256


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Description

Description

The mediator complex is a multi-protein transcriptional co-activator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factor. One of the proteins in this complex is MED28, also known as Magicin. MED28 is expressed in many cell lines and tissues. It has been shown that a down-regulation of MED28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell differentiation and conversely its over-expression represses expression of SMC genes. MED28 can also form a ternary complex with Grb2 and Merlin, the neurofibromatosis 2 tumor suppressor protein, indicating that MED28 may play a role in Merlin ft.s tumor suppressive activity. MED28 has also been recently identified as an HIV dependency factor (HDF), suggesting that MED28 may be an important drug target in HIV treatment. At least two isoforms of MED28 are known to exist.
Specifications

Specifications

MED28
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9H204
FKSG20, 1500003D12Rik, EG1, magicin; endothelial-derived gene 1; endothelial-derived protein 1; mediator of RNA polymerase II transcription subunit 28; mediator of RNA polymerase II transcription, subunit 28 homolog; merlin and Grb2-interacting cytoskeletal protein; tumor angiogenesis marker EG-1
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
80306
Immunohistochemistry (Paraffin), Western Blot
OTI10C8
Unconjugated
MED28
Liquid
MED28
Full length human recombit protein of MED28 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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