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Invitrogen™ MEF2A/MEF2C Recombinant Rabbit Monoclonal Antibody (10I9G9)
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Catalog No. PIMA542794
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100 μL
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PIMA542794 100 μL
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Catalog No. PIMA542794 Supplier Invitrogen™ Supplier No. MA542794
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Description

Rabbit Recombinant Monoclonal Antibody

Positive test controls include: RD, Mouse brain. Immunogen sequence: NRKPDLRVLI PPGSKNTMPS VSEDVDLLLN QRINNSQSAQ SLATPVVSVA TPTLPGQGMG GYPSAISTTY GTEYSLSSAD LSSLSGFNTA SALHLGSVTG WQQQHLHNMP PSALSQLGAC TSTHLSQSSN LSLPSTQSLN IKSEPVSPPR DRTTTPSRYP QHTRHEAGRS PVDSLSSCSS SYDGSDREDH RNEFHSPIGL TRPSPDERES PSVKRMRLSE GWAT.

MEF2A is found in many muscle specific-genes mediating cellular functions in skeletal and cardiac muscle. MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MEF2A/MEF2C
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone 10I9G9
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene MEF2A
Gene Accession No. Q02078, Q06413, Q60929, Q8CFN5
Gene Alias ADCAD1; C5DELq14.3; DEL5q14.3; mef2; NEDHSIL; RSRFC4; RSRFC9
Gene Symbols MEF2A, MEF2C
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 250-473 of human MEF2A+MEF2C (Q06413).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17258, 17260, 4205, 4208
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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