Invitrogen™ MEF2A/MEF2C Recombinant Rabbit Monoclonal Antibody (10I9G9)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542794

Catalog No. PIMA542794

Description

Positive test controls include: RD, Mouse brain. Immunogen sequence: NRKPDLRVLI PPGSKNTMPS VSEDVDLLLN QRINNSQSAQ SLATPVVSVA TPTLPGQGMG GYPSAISTTY GTEYSLSSAD LSSLSGFNTA SALHLGSVTG WQQQHLHNMP PSALSQLGAC TSTHLSQSSN LSLPSTQSLN IKSEPVSPPR DRTTTPSRYP QHTRHEAGRS PVDSLSSCSS SYDGSDREDH RNEFHSPIGL TRPSPDERES PSVKRMRLSE GWAT.

MEF2A is found in many muscle specific-genes mediating cellular functions in skeletal and cardiac muscle. MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Specifications

• Antigen: MEF2A/MEF2C
• Classification: Recombinant Monoclonal
• Concentration: 0.7 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q02078, Q06413, Q60929, Q8CFN5
• Gene Symbols: MEF2A, MEF2C
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-473 of human MEF2A+MEF2C (Q06413).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 10I9G9
• Conjugate: Unconjugated
• Gene: MEF2A
• Gene Alias: ADCAD1; C5DELq14.3; DEL5q14.3; mef2; NEDHSIL; RSRFC4; RSRFC9
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17258, 17260, 4205, 4208
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

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