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Invitrogen™ MEF2C Polyclonal Antibody
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Catalog No. PIPA5116971
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100 μL
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PIPA5116971 100 μL
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Catalog No. PIPA5116971 Supplier Invitrogen™ Supplier No. PA5116971
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Description

Rabbit Polyclonal Antibody

Positive Samples: Jurkat, NIH/3T3, 293T, HeLa, Mouse skeletal muscle Immunogen sequence: LPLAHPSLQR NSMSPGVTHR PPSAGNTGGL MGGDLTSGAG TSAGNGYGNP RNSPGLLVSP GNLNKNMQAK SPPPMNLGMN NRKPDLRVLI PPGSKNTMPS VSEDVDLLLN QRINNSQSAQ SLATPVVSVA TPTLPGQGMG GYPSAISTTY GTEYSLSSAD LSSLSGFNTA SALHLGSVTG WQQQHLHNMP PSALSQLGAC TSTHLSQSSN L.

MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MEF2C
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 2.61 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene MEF2C
Gene Accession No. Q06413, Q8CFN5
Gene Alias 5430401D19Rik; 9930028G15Rik; AV011172; C5DELq14.3; DEL5q14.3; hoo; hoover; id:ibd5026; MADS box transcription enhancer factor 2, polypeptide C; Mef2; mef2c; mef2c protein; mef2ca; Myocyte enhancer factor 2C; myocyte enhancer factor 2C MEF2C; myocyte enhancer factor 2ca; myocyte enhancer factor 2ca 4'-6'; myocyte enhancer factor 2ca delta gamma-like; myocyte enhancer factor 2ca variant 4; myocyte enhancer factor 2ca variant 5; myocyte enhancer factor 2ca variant 6; myocyte enhancer factor 2ca; myocyte-specific enhancer factor 2C; myocyte-specific enhancer factor 2C; RGD1563119; wu:fc05b06; zgc:64184; zgc:85726
Gene Symbols MEF2C
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 170-380 of human MEF2C (NP_0023882).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17260, 4208, 499497
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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