Invitrogen™ MEIKIN Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5144240

Catalog No. FEPA5144240

Description

MEIKIN Polyclonal Antibody for IHC (P), ELISA

Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.

Specifications

• Antigen: MEIKIN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MEIKIN
• Gene Alias: MEIKINMeiosis-specific kinetochore protein
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 728637
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin)
• Concentration: 4 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4
• Gene Accession No.: A0A087WXM9
• Gene Symbols: MEIKIN
• Immunogen: Recombinant Human Meiosis-specific kinetochore protein (18-91AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG