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Invitrogen™ MEIKIN Polyclonal Antibody
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Catalog No. FEPA5144240
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100 μg
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FEPA5144240 100 μg
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Catalog No. FEPA5144240 Supplier Invitrogen™ Supplier No. PA5144240
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Description

Rabbit Polyclonal Antibody

MEIKIN Polyclonal Antibody for IHC (P), ELISA

Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MEIKIN
Applications ELISA, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 4 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4
Gene MEIKIN
Gene Accession No. A0A087WXM9
Gene Alias MEIKINMeiosis-specific kinetochore protein
Gene Symbols MEIKIN
Host Species Rabbit
Immunogen Recombinant Human Meiosis-specific kinetochore protein (18-91AA).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 728637
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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