Invitrogen™ MEK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA586179

Catalog No. PIPA586179

Description

Purity is > 95% by SDS-PAGE.

MAP2K2 (MEK2) is a dual specificity serine/threonine kinase that is known to play a critical role in mitogen growth factor signal transduction. Mitogen activated protein kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.

Specifications

• Antigen: MEK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAP2K2
• Gene Alias: AA589381; CFC4; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; ERK kinase 2; FLJ26075; MAP kinase kinase 2; MAP kinase/Erk kinase; MAP2K1; MAP2K2; MAPK; MAPK/ERK kinase 1; MAPK/ERK kinase 2; MAPKK 1; MAPKK 2; MAPKK2; MEK 1; MEK 2; MEK-1; Mek2; MEK-2; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MK2; MKK1; Mkk2; OTTHUMP00000165827; PRKMK1; PRKMK2; protein kinase, mitogen activated, kinase 2, p45
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26396, 5605, 58960
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P36506, P36507, Q63932
• Gene Symbols: MAP2K2
• Immunogen: Synthetic peptide, corresponding to amino acids C-terminus of Human MEK-2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov