Invitrogen™ MEK3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA517480

Catalog No. PIPA517480

Description

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with MEK1, MEK2, MKK4 or MKK6.

MAP2K3 (MEK3) is a dual-specificity protein kinase which acts in cellular signal transduction pathways, and is necessary for the expression of glucose transporter. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for MEK3.

Specifications

• Antigen: MEK3
• Classification: Polyclonal
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: O09110, P46734
• Gene Symbols: MAP2K3
• Immunogen: Synthetic peptide corresponding to the N-terminal sequence of human MKK3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Gene: MAP2K3
• Gene Alias: AW212142; dual specificity mitogen-activated protein kinase kinase 3; EC 2.7.12.2; MAP kinase kinase 3; Map2k3; MAPK/ERK kinase 3; MAPKK 3; MAPKK3; MEK 3; Mek3; mitogen activated protein kinase kinase 3; mitogen-activated protein kinase kinase 3; Mkk3; mMKK3b; Prkmk3; protein kinase, mitogen-activated, kinase 3; SAPK kinase 2; SAPKK2; SAPKK-2; SKK2; Stress-activated protein kinase kinase 2
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 26397, 303200, 5606
• Content And Storage: -20°C
• Form: Liquid