Invitrogen™ MEK5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529236

Catalog No. PIPA529236

Description

Recommended positive controls: U87-MG. Predicted reactivity: Mouse (98%), Rat (98%), Chicken (91%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

MAP2K5 (MEK5) serine/threonine kinase (mitogen-activated protein kinase 5) or MEK5 is a dual specificity protein kinase that belongs to the MAP kinase family which specifically interacts with and activates MAPK7/ERK5. MAP2K5 itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by MAP2K5 is involved in growth factor stimulated cell proliferation and muscle cell differentiation. The rs3743354 polymorphism in the MAP2K5 promoter may affect the risk of developing colorectal cancer (CRC).

Specifications

• Antigen: MEK5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAP2K5
• Gene Alias: AI324775; AI428457; Dual specificity mitogen-activated protein kinase kinase 5; HsT17454; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAP2K5; MAPK/ERK kinase 5; MAPK/ERK kinese 5; MAPKK 5; Mapkk5; MEK 5; MEK5; mitogen activated protein kinase kinase 5; mitogen-activated protein kinase kinase 5; Mkk5; PRKMK5
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5607
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q13163
• Gene Symbols: MAP2K5
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 205 of Human MEK5.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG