Invitrogen™ MEKK4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552459

Catalog No. PIPA552459

Description

Immunogen sequence: KDREQRGQEN TSGFWLNRSN ELIWLELQAW HAGRTINDQD FFLYTARQAI PDIINEILTF KVDYGSFAFV RDRAGFNGTS VEGQCKATPG TKIVGYSTHH EHLQRQRVSF EQVKRIMELL EYIEALYPSL Q Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 85%.

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

Specifications

• Antigen: MEKK4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAP3K4
• Gene Alias: D17Rp17; D17Rp17e; dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4); JNKK1; KIAA0213; MAP three kinase 1; MAP/ERK kinase kinase 4; MAP2K4; Map3k4; MAPK/ERK kinase kinase 4; MAPKKK4; MEK kinase 4; Mek4b; MEKK 4; MEKK4; mitogen activated protein kinase kinase kinase 4; mitogen-activated protein kinase kinase kinase 4; mKIAA0213; MTK1; predicted protein of HQ0412; PRKMK4; PRO0412; RP17; Rp17a; SAPK/ERK kinase 1; SERK1; SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of; Tas; T-associated sex reversal
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4216
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y6R4
• Gene Symbols: MAP3K4
• Immunogen: Recombinant protein corresponding to Human MEKK4. Recombinant protein control fragment (Product #RP-89772).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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