Invitrogen™ MEL18 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA566592

Catalog No. PIPA566592

Description

Immunogen sequence: PSEGTNTSGAS ECESVSDKAP SPATLPATSS SLPSPATPSH GS Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.

Specifications

• Antigen: MEL18
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCGF2
• Gene Alias: DNA-binding protein Mel-18; Mel18; Mel-18; Melanoma nuclear protein 18; MGC10545; Pcgf2; polycomb group ring finger 2; polycomb group RING finger protein 2; RING finger protein 110; RNF110; Zfp144; Zfp-144; Zinc finger protein 144; zinc finger protein 144 (Mel-18) (human homolog); ZNF144
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7703
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P35227
• Gene Symbols: PCGF2
• Immunogen: Recombinant Human MEL18. Recombinant protein control fragment (Product #RP-107245).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG