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Invitrogen™ MEL18 Polyclonal Antibody
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Catalog No. PIPA5111259
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100 μL
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PIPA5111259 100 μL
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Catalog No. PIPA5111259 Supplier Invitrogen™ Supplier No. PA5111259
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SLSIEFYEGA RDRDEKKGPL ENGDGDKEKT GVRFLRCP Highest antigen sequence indentity to the following orthologs: Rat - 87%, Mouse - 87%.

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MEL18
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PCGF2
Gene Accession No. P35227
Gene Alias DNA-binding protein Mel-18; Mel18; Mel-18; Melanoma nuclear protein 18; MGC10545; Pcgf2; polycomb group ring finger 2; polycomb group RING finger protein 2; RING finger protein 110; RNF110; Zfp144; Zfp-144; Zinc finger protein 144; zinc finger protein 144 (Mel-18) (human homolog); ZNF144
Gene Symbols PCGF2
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human MEL18. Recombinant protein control fragment (Product #RP-100379).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7703
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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