Invitrogen™ Melanophilin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100044

Catalog No. PIPA5100044

Description

Antibody detects endogenous levels of total Melanophilin.

Slac2-a (for synaptotagmin-like protein (Slp) homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes. Slac2-a binds Myosin VA through a C-terminal region and GTP-bound Rab27A through its synaptotagmin-like protein homology domain (SHD), which is located near the N-terminus. The transport of pigment and cytotoxic granules in melanocytes requires the stable formation of this complex, and thus mutations in the binding domains of the three protein components may cause albinism and/or severe immune disorders.

Specifications

• Antigen: Melanophilin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mlph
• Gene Alias: 2210418F23Rik; 5031433I09Rik; AW228792; D1Wsu84e; Exophilin-3; l(1)-3Rk; l1Rk3; leaden; leaden protein; Ln; Melanophilin; MGC2771; MGC59733; Mlph; OTTMUSP00000025451; SLAC2A; Slac-2a; SlaC2-a; Slp homolog lacking C2 domains a; synaptotagmin-like protein 2a
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 171531, 316620, 79083
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q91V27, Q9BV36
• Gene Symbols: Mlph
• Immunogen: A synthesized peptide derived from human MLPH(Accession Q9BV36), corresponding to amino acid residues K539-H589.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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