Invitrogen™ Melanophilin Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA518050

Catalog No. PIPA518050

Description

This antibody is predicted to react with rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

Slac2-a (for synaptotagmin-like protein (Slp) homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes. Slac2-a binds Myosin VA through a C-terminal region and GTP-bound Rab27A through its synaptotagmin-like protein homology domain (SHD), which is located near the N-terminus. The transport of pigment and cytotoxic granules in melanocytes requires the stable formation of this complex, and thus mutations in the binding domains of the three protein components may cause albinism and/or severe immune disorders.

Specifications

• Antigen: Melanophilin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mlph
• Gene Alias: 2210418F23Rik; 5031433I09Rik; AW228792; D1Wsu84e; Exophilin-3; l(1)-3Rk; l1Rk3; leaden; leaden protein; Ln; Melanophilin; MGC2771; MGC59733; Mlph; OTTMUSP00000025451; SLAC2A; Slac-2a; SlaC2-a; Slp homolog lacking C2 domains a; synaptotagmin-like protein 2a
• Host Species: Goat
• Purification Method: Ammonium Sulfate Precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 171531
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: GST Pull Down, Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q91V27
• Gene Symbols: Mlph
• Immunogen: Synthetic peptide sequence (ARHIFAKPVMAQQP) corresponding to the C-terminus amino acids of Mlph (aa 577-590).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG