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Invitrogen™ MELK Monoclonal Antibody (2G2)
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Catalog No. PIMA517120
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100 μg
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PIMA517120 100 μg
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Catalog No. PIMA517120 Supplier Invitrogen™ Supplier No. MA517120
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Description

Mouse Monoclonal Antibody

MA5-17120 targets MELK in indirect ELISA, FACS, ICC, IHC, and IF applications and shows reactivity with Human samples. The MA5-17120 immunogen is synthesized peptide of human MELK(amino acids: 637-651:C-VYKRLVEDILSSCKV). MA5-17120 detects MELK which has a predicted molecular weight of approximately 74.6kDa.

MELK is a serine/threonione kinase which is related to the AMPK family that has been linked to the cell cycle. MELK has also been shown to be overexpressed in cancer and has been identified has a potential target for cancer therapeutics. MELK has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MELK
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Monoclonal
Clone 2G2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene MELK
Gene Accession No. Q14680
Gene Alias AI327312; hMELK; HPK38; Kiaa0175; Maternal embryonic leucine zipper kinase; Melk; mKIAA0175; MPK38; OTTHUMP00000046113; pEg3 kinase; Pk38; Protein kinase Eg3; protein kinase PK38; RP11-8N6.1; Tyrosine-protein kinase MELK
Gene Symbols MELK
Host Species Mouse
Immunogen Synthesized peptide of human MELK(amino acids: 637-651:C-VYKRLVEDILSSCKV).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9833
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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