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Invitrogen™ Menin Polyclonal Antibody
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Catalog No. PIPA583140
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100 μL
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PIPA583140 100 μL
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Catalog No. PIPA583140 Supplier Invitrogen™ Supplier No. PA583140
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DPLTLYHKGI ASAKTYYRDE HIYPYMYLAG YHCRNRNVRE ALQAWADTAT VIQDYNYCRE DEEIYKEFFE VANDVIPNLL Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 99%.

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Menin
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MEN1
Gene Accession No. O00255
Gene Alias AW045611; MEAI; MEN1; Menin; menin 1; multiple endocrine neoplasia 1; multiple endocrine neoplasia I; SCG2
Gene Symbols MEN1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human MEN1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4221
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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