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Invitrogen™ Menin Polyclonal Antibody
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Catalog No. PIPA585330
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100 μL
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PIPA585330 100 μL
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Catalog No. PIPA585330 Supplier Invitrogen™ Supplier No. PA585330
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Description

Rabbit Polyclonal Antibody

Keep as concentrated solution. Predicted reactivity: Mouse (97%), Rat (97%), Dog (99%), Bovine (98%). Positive Control: Jurkat, Raji. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Menin
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1.03 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene MEN1
Gene Accession No. O00255
Gene Alias AW045611; MEAI; MEN1; Menin; menin 1; multiple endocrine neoplasia 1; multiple endocrine neoplasia I; SCG2
Gene Symbols MEN1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Menin. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4221
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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