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  6. Menin Rabbit anti-Human, Mouse, Unconjugated, Polyclonal, Active Motif™ 

Menin Rabbit anti-Human, Mouse, Unconjugated, Polyclonal, Active Motif™
SDP

Catalog No. 501993839
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50-199-3839 10 μL
50-199-3838 100 μL
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Catalog No. 50-199-3839 Supplier Active Motif Supplier No. 61006
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Description

Rabbit Polyclonal Antibody

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.

Specifications

Antigen Menin
Applications ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot
Classification Polyclonal
Concentration Lot-Specific
Conjugate Unconjugated
Formulation 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene MEN1
Gene Accession No. O00255, O88559
Gene Alias AW045611; MEAI; MEN1; Menin; menin 1; multiple endocrine neoplasia 1; multiple endocrine neoplasia I; SCG2
Gene Symbols MEN1
Host Species Rabbit
Immunogen This Menin antibody was raised against a peptide corresponding to amino acids within the C-terminal region of human Menin.
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17283, 4221
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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