Invitrogen™ Menin Recombinant Rabbit Monoclonal Antibody (5M7L9)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542807

Catalog No. PIMA542807

Description

Positive test controls include: HeLa, HCT116, HepG2, NIH/3T3, Mouse lung, Mouse brain, Rat lung, Rat brain. The target is usually found in the following locations: Nucleus. Immunogen sequence: VSGPPRKPPG TVAGTARGPE GGSTAQVPAP TASPPPEGPV LTFQSEKMKG MKELLVATKI NSSAIKLQLT AQSQVQMKKQ KVSTPSDYTL SFLKRQRKGL.

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.

Specifications

• Antigen: Menin
• Classification: Recombinant Monoclonal
• Concentration: 0.58 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O00255, O88559, Q9WVR8
• Gene Symbols: MEN1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 516-615 of human Menin (O00255).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 5M7L9
• Conjugate: Unconjugated
• Gene: MEN1
• Gene Alias: AW045611; MEAI; MEN1; Menin; menin 1; multiple endocrine neoplasia 1; multiple endocrine neoplasia I; SCG2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17283, 29417, 4221
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid