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Invitrogen™ MEP1B Monoclonal Antibody (289731)
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Catalog No. PIMA523991
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100 μg
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Catalog No. Quantity
PIMA523991 100 μg
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Catalog No. PIMA523991 Supplier Invitrogen™ Supplier No. MA523991
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Description

Rat Monoclonal Antibody

This antibody detects the pro form of human or mouse Meprin beta Subunit/MEP1B in Western blots. This antibody does not react with the mature form. Reconstitute at 0.5 mg/mL in sterile PBS.

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MEP1B
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 289731
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Mep1b
Gene Accession No. Q16820, Q61847
Gene Alias EC 3.4.24.63; Endopeptidase-2; MEP1B; Mep-1b; meprin 1 beta; meprin A; meprin A subunit beta; meprin A, beta; meprin B; meprin beta; N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta
Gene Symbols Mep1b
Host Species Rat
Immunogen Human embryonic kidney cell line HEK293-derived recombinant human Meprin beta Subunit/MEP1B Thr23-Ser293.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17288, 4225
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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