Invitrogen™ MEP1B Monoclonal Antibody (289731)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA523991

Catalog No. PIMA523991

Description

This antibody detects the pro form of human or mouse Meprin beta Subunit/MEP1B in Western blots. This antibody does not react with the mature form. Reconstitute at 0.5 mg/mL in sterile PBS.

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.

Specifications

• Antigen: MEP1B
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q16820, Q61847
• Gene Symbols: Mep1b
• Immunogen: Human embryonic kidney cell line HEK293-derived recombinant human Meprin beta Subunit/MEP1B Thr23-Ser293.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: 289731
• Conjugate: Unconjugated
• Gene: Mep1b
• Gene Alias: EC 3.4.24.63; Endopeptidase-2; MEP1B; Mep-1b; meprin 1 beta; meprin A; meprin A subunit beta; meprin A, beta; meprin B; meprin beta; N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 17288, 4225
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized